Dielectric spectroscopy of a 10% solution of human immunoglobulin G at physiological temperatures. Part 1
DOI:
https://doi.org/10.33910/2687-153X-2025-6-2-69-86Keywords:
dielectric constant of immunoglobulin G, dielectric losses of IgG, relaxation parameters of IgG, Havriliak–Negami equation, phase transitions, globule–tangle, immunoglobulinsAbstract
In this paper, the dielectric and relaxation properties of a 10% water solution of human immunoglobulin are investigated in the frequency range of 0.1 Hz to 15 MHz at temperatures between 35 and 39.7 °C. The frequency dependences of the dielectric loss factor ε" were obtained, revealing three maxima in the dispersion regions ε'. These maxima were approximated by the Havriliak–Negami equation. For each relaxation process, the parameters α, β, and τ0 were calculated at different temperatures, and the time distribution functions of the relaxers, G(t), were derived. The paper proposes possible interpretations of the kinetic units responsible for these processes and discusses potential phase transitions within the system.
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